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Our Approach

ABC² believes that a nimble, focused and aggressive entrepreneurial model will increase the number of therapies discovered and then enable those therapies to be more rapidly driven into the clinic. We provide researchers with the pivotal support they need to make critical breakthroughs and fund novel translational research aimed at finding the fastest possible route to a cure for brain cancer.

Brain Tumor Facts

More than 200,000 people in the United States will be diagnosed with a primary or metastatic brain tumor over the next twelve months.

Brain tumors…

    * are a leading cause of cancer death among children and young adults.
    * cannot be prevented because their causes are currently unknown.
    * require increased public awareness & research funding if we hope to end this devastating disease.

Our Impact

Since its founding in 2001 by Steve and Dan Case, ABC² has provided more than $15 million in research funding to highly qualified research investigators and physician-scientists from 36 institutions.

In 2009, ABC² played a key role in convincing The National Cancer Institute to study Glioblastoma multiforme (GBM), the most common and most aggressive type of brain tumor, as the first cancer to be analyzed for the Cancer Genome Atlas.


Our mission is clear: to accelerate the development of treatments that will lead to a cure for brain cancer.

Our Story

Daniel H. Case, III (1957-2002) Dan Case Photo
In 2001, Dan Case was diagnosed with brain cancer. Discouraged by a lack of information and limited treatment options, Dan, together with his brother, Steve Case, and their families, founded Accelerate Brain Cancer Cure (ABC²). Accelerate Brain Cancer Cure is a non-profit organization that partners with leading entrepreneurs, scientists and researchers to find a cure for brain cancer.

With his finance background, Dan recognized that few biotechnology and pharmaceutical companies were willing to invest research and development dollars toward brain cancer research due to its relative scarcity. By “buying down the risk” in the drug discovery process, Accelerate Brain Cancer Cure is able to speed up the drug discovery process. ABC² applies entrepreneurial approaches to medical research and bridges the gap which often exists between academic researchers who often make significant scientific discoveries and companies which bring those treatments to patients. Since 2001, Accelerate Brain Cancer Cure has provided more than $6 million in research funding to highly qualified research investigators and physician-scientists from 22 institutions.

Daniel H. Case, III, was one of the world’s leading investment bankers and a driving force in the world of venture capital. Dan served as Chairman of the Board of JPMorgan H&Q (formerly Hambrecht & Quist), a legendary investment banking firm that specialized in the financing of entrepreneurial companies whose clients included Apple Computer, Genentech, Adobe Software, and Netscape.

Accelerate Brain Cancer Cure operates in honor and celebration of Dan Case, a husband, father, brother, son, colleague, counselor, leader and friend.

To learn more about Accelerate Brain Cancer Cure and other projects visit:


Accelerate Brain Cancer Cure | 1717 Rhode Island Ave, NW, 7th Floor, Washington, DC 20036 | 202-419-3140 |